Geological mapping and U–Pb geochronology of the Klondike District provide new information on the nature and evolution of the Yukon–Tanana terrane (YTT) in western Yukon. The area is underlain by a sequence of thrust panels of regional extent. A continuously mappable sequence of interlayered metasedimentary and metavolcanic rocks is intruded by a variety of deformed metaplutonic rocks within two of these thrust sheets. Layering in the metasediments and metavolcanics is considered to be at least in part transposed stratigraphy. Small bodies of greenstone and altered ultramafic rocks thought to be part of the Slide Mountain terrane occur discontinuously along the thrust faults.U–Pb age determinations indicate that the uppermost thrust panel (assemblage I), which underlies much of the Klondike District, consists largely of metamorphosed, mid-Permian felsic plutonic, subvolcanic, and tuffaceous rocks. Beneath assemblage I is a second thrust panel (assemblage II), also of large areal extent, of mid-Paleozoic or older metasedimentary and mafic and felsic metavolcanic rocks, intruded by a large body of latest Devonian – Early Mississippian granitic augen orthogneiss. U–Pb analyses of zircon from the orthogneiss reflect both lead loss and a significant inherited zircon component. A third structural unit (assemblage III), which consists mainly of carbonaceous schist and phyllite, crops out in the northern part and along the southwestern edge of the study area, where it underlies both assemblages I and II.The earliest stage of deformation and metamorphism that affected the area (F1) produced the pervasive recrystallization fabric characteristic of all of the metamorphic rocks in assemblages I, II, and III, and occurred between mid-Permian and Late Triassic time. Thrust faulting, presumed to be northerly or northeasterly directed, postdates Late Triassic but predates mid-Cretaceous. The second phase of deformation (F2) was either synchronous with or later than thrust faulting. Monazite ages for the augen orthogneiss indicate that at least local metamorphism and (or) deformation lasted until Early Cretaceous time.Close similarities between composition, U–Pb ages, as well as timing and style of deformation, documented in the Klondike District and observed elsewhere in the YTT in southeastern Yukon and east-central Alaska suggest that much of the YTT either evolved as a single entity or else shared a very similar history.